Grapefruit and Zylö Therapeutics Forge Partnership That Promises to Disrupt the Topical Cannabis Market

Grapefruit and Zylö Therapeutics

    • Grapefruit’s Hourglass™ Topical Delivery Cream is the world’s first and only known meaningfully effective THC + Cannabinoid-loaded transdermal capable of penetrating the five layers of human skin, “breaking” through the dermal pathway, and penetrating the human blood-brain barrier to deliver beneficial cannabinoids to the bloodstream in a predictable, steady dose over time.
    • In simpler terms, Grapefruit’s Hourglass™ is the world’s first topical cannabis cream that can actually get you high and deliver both central and peripheral benefits in a sustained-release manner.
    • The partnership between Grapefruit and Zylö grants Grapefruit exclusive rights to Zylö’s patented Z-pod technology in the United States, Canada, and Mexico.

LOS ANGELES, CA, September 4, 2020, Grapefruit USA, Inc., (OTCQB: GPFT) (“Grapefruit” or the “Company”) a California based cannabis company, and Zylö Therapeutics Inc. (“Zylö”) developer of the transformational Z-pod topical delivery platform, announced that it has entered into an exclusive agreement for Zylö to supply its patented Z-pod system as the technological underpinning of Grapefruit’s disruptive Hourglass time-release cannabinoid topical cream.

Grapefruit’s Hourglass delivery cream is formulated such that it enables a Patchless Patch product concept, whereby a topically applied cream provides a ‘patch-like’ sustained release of THC and Cannabinoids but without the hassles, inconvenience, skin sensitivity and disposal issues of a patch.  Grapefruit’s delivery system facilitates full dermal penetration, improves stability, and enhances overall bioavailability. No other topical cannabis products on the market are capable of producing a full spectrum of benefits for the consumer in such a safe, healthy, discrete, and convenient manner.

Grapefruit, which holds licenses in California to manufacture and distribute cannabis products (see, has exclusivity initially in the United States and has certain rights to expand the territory of exclusivity to Canada and Mexico. Canada has a well-established legalized cannabis marketplace, and it is anticipated that Mexico will legalize cannabis in the near future.

Grapefruit plans to introduce Hourglass on a limited basis to the California retail market by the beginning of the fourth quarter and to ramp up production and delivery of the product shortly thereafter. The architecture of the Hourglass delivery cream provides Grapefruit with the ability to formulate variations of its Hourglass product concept by loading the cream with unique blends of cannabinoids that its customers deem to be efficacious for a given application or desired result.

Scott Pancoast, Zylö’s CEO and founder, stated “We are enthusiastic about this partnership with Grapefruit and believe their Hourglass Topical Delivery Cream will be a game-changer in the recreational/medicinal full-spectrum cannabis market given the extraordinary advantages over traditional methods of consuming cannabis. We look forward to a long and expanding relationship with the Grapefruit team.”

Added Bradley J. Yourist, Grapefruit’s CEO, “We are excited and proud to have completed the developmental phase of Hourglass, our breakthrough full-spectrum cannabinoid time-release topical delivery cream based on Zylö’s patented xerogel silica delivery system.  We have developed an incredible collaborative working relationship with the Zylö team of scientists, which is evidenced by the scope of our agreement. We believe that Grapefruit’s Hourglass topical delivery cream is a truly disruptive, breakthrough technology, one that fundamentally changes the way individuals will use cannabinoids to obtain their unique benefits because the Z-podsystem allows our THC+CDB actives to pass the blood brain barrier. Destructive and socially distasteful smoking of cannabis flowers and consumption of edibles that are metabolized unevenly are simply no longer necessary to enjoy both the medicinal and recreational benefits of cannabinoids. Furthermore, Grapefruit’s Hourglass Topical Delivery Cream offers cannabis users a heretofore unattainable level of discretion and anonymity. For example, fellow airline, train or ship passengers, concert goers, and movie or theatre attendees will not be able to detect any telltale odors normally associated with cannabis use.”

Watch These Videos to Learn More about Hourglass by Grapefruit:

About Grapefruit

Grapefruit holds licenses in California to both manufacture and distribute cannabis products (see website at The Company’s extraction lab produces high quality, cannabis-derived THC and full-spectrum distillates commonly known as “honey oil” and “crude oil” from cannabis flower and “trim”. These distillates are base cannabis commodities and are the active ingredients in many cannabis products including infused edibles, tinctures, and creams, and are also used as the active ingredient in vaporization cartridges. Grapefruit also distributes branded cannabis and cannabis products to properly licensed cannabis product companies, including the Sugar Stoned™ line of cannabis and CBD-infused edibles (see and the breakthrough Hourglass™ sustained-release THC+Cannabinoid Topical Delivery Cream (see

Safe Harbor Statement

Grapefruit cautions you that any statement included in this press release that is not a description of historical facts is a forward-looking statement. Many of these forward-looking statements contain the words “anticipate,” “believe,” “estimate,” “may” “intend,” “expect” and similar expressions. Actual results, performance or achievements could differ materially from those contemplated, expressed or implied by the forward-looking statements contained herein. These forward-looking statements are based largely on the expectations of the company and are subject to a number of risks and uncertainties inherent in Grapefruit’s business, including, without limitation: the company may not ever obtain additional funds necessary to support its business development and growth plans; and the company may not ever achieve the market success to reach or sustain a profitable business. In addition, there are risks and uncertainties related to economic recession or terrorist actions, competition from much larger cannabis companies, unexpected costs and delays, potential product liability claims, and many other factors. More detailed information about Grapefruit and the risk factors that may affect the realization of forward-looking statements is set forth in the Company’s filings with the Securities and Exchange Commission, including the company’s Annual Report on Form 10-K, its Quarterly Report on Form 10-Q/A for the period ended March 31, 2020 and its Registration Statement on Form S-1/A. Such documents may be read free of charge on the SEC’s website at You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, and Grapefruit undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof. This caution is made under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995.


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